Our Technology

Gemneo’s DNA Origami Nanoprobes for Single-Cell Genomics can drastically reduce the time and expense of profiling genetically diverse tissues like those found in cancer, immune systems, and microbiomes.

The Gemneo product can greatly improve on the performance metrics vs existing single-cell technologies, and eliminates tradeoffs between those metrics.


A Needle in a Haystack

Finding and characterizing rare cells is critical to understanding the immune system, cancer, and microbiomes. It is also critical for the development of immunotherapies. Finding rare cells is akin to finding a needle in a haystack. The faster and more economically you can sift through the hay, the faster and cheaper it is to find the needles.

The key metrics that determine performance for single-cell genomics tools and methods are:

Looking for Rare Cells

Throughput equals resolution in genomic profiling when looking for rare cells. This concept is analogous to the resolution of a digital camera image. The more pixels in the image, the more fine details you can see. The same goes for genomic profiling, the more cells you can profile, the greater chance of seeing the rare cell types in the population. Current techniques and tools are slow (low throughput), costly, and inefficient, and often require tradeoffs between the performance metrics. If you choose higher throughput and lower cost, the efficiency goes down. If you choose higher efficiency, throughput goes down and costs go up. The Gemneo technique can process millions of cells in a single test tube, and requires no special equipment. A single technician could generate data from 1 billion cells in a day, at a fraction of the cost (in equipment, labor, and/or consumables) than all other methods.